Hirata, A. S., La Clair, J. J., Jimenez, P. C., Costa-Lotufo, L. V., & Fenical, W. (2022). Preclinical Development of Seriniquinones as Selective Dermcidin Modulators for the Treatment of Melanoma. Marine Drugs, 20(5). https://doi.org/10.3390/md20050301

Castro-Falcon, G., Creamer, K. E., Chase, A. B., Kim, M. C., Sweeney, D., Glukhov, E., Fenical, W., & Jensen, P. R. (2022). Structure and candidate biosynthetic gene cluster of a manumycin-type metabolite from Salinispora pacifica. Journal of Natural Products, 85(4), 980–986. https://doi.org/10.1021/acs.jnatprod.1c01117

Shing, B., Balen, M., Fenical, W., & Debnath, A. (2022). Development of a machine learning-based cysticidal assay and identification of an amebicidal and cysticidal marine microbial metabolite against Acanthamoeba. Microbiology Spectrum, 10. https://doi.org/10.1128/spectrum.00077-22

Lee, S. E., Kim, M. J., Hillman, P. F., Oh, D. C., Fenical, W., Nam, S. J., & Lim, K. M. (2022). Deoxyvasicinone with anti-melanogenic activity from marine-derived Streptomyces sp. CNQ-617. Marine Drugs, 20(2). https://doi.org/10.3390/md20020155

Kim, S., Le, T. C., Han, S. A., Hillman, P. F., Hong, A., Hwang, S., Du, Y. E., Kim, H., Oh, D. C., Cha, S. S., Lee, J., Nam, S. J., & Fenical, W. (2022). Saccharobisindole, neoasterric methyl ester, and 7-chloro-4(1H)-quinolone: Three new compounds isolated from the marine bacterium Saccharomonospora sp. Marine Drugs, 20(1), 12. https://doi.org/10.3390/md20010035

Le, T. C., Pulat, S., Lee, J., Kim, G. J., Kim, H., Lee, E. Y., Hillman, P. F., Choi, H., Yang, I., Oh, D. C., Nam, S. J., & Fenical, W. (2022). Marine depsipeptide nobilamide i inhibits cancer cell motility and tumorigenicity via suppressing epithelial-mesenchymal transition and MMP2/9 expression. Acs Omega, 11. https://doi.org/10.1021/acsomega.1c04520

Kim, M. C., Li, Z. F., Cullum, R., Molinski, T. F., Eid, M. A. G., Hebishy, A. M. S., Faraag, A. H. I., Moneim, A. E. A., Abdelfattah, M. S., & Fenical, W. (2022). Chlororesistoflavins A and B, Chlorinated Benzopyrene Antibiotics Produced by the Marine-Derived Actinomycete Streptomyces sp. Strain EG32. Journal of Natural Products, 6. https://doi.org/10.1021/acs.jnatprod.1c01084

Hirata, A. S., Rezende-Teixeira, P., Machado-Neto, J. A., Jimenez, P. C., Clair, J. J. L., Fenical, W., & Costa-Lotufo, L. V. (2021). Seriniquinones as therapeutic leads for treatment of BRAF and NRAS mutant melanomas. Molecules, 26(23), 15. https://doi.org/10.3390/molecules26237362

Kim, M. C., Winter, J. M., Asolkar, R. N., Boonlarppradab, C., Cullum, R., & Fenical, W. (2021). Marinoterpins A-C: Rare linear merosesterterpenoids from marine-derived actinomycete bacteria of the family Streptomycetaceae. Journal of Organic Chemistry, 86(16), 11140–11148. https://doi.org/10.1021/acs.joc.1c00262

Kim, S., Lee, C. W., Park, S. Y., Asolkar, R. N., Kim, H., Kim, G. J., Oh, S. J., Kim, Y., Lee, E. Y., Oh, D. C., Yang, I., Paik, M. J., Choi, H., Nam, S. J., & Fenical, W. (2021). Acremonamide, a cyclic pentadepsipeptide with wound-healing properties isolated from a marine-derived fungus of the genus Acremonium. Journal of Natural Products, 84(8), 2249–2255. https://doi.org/10.1021/acs.jnatprod.1c00305

Taylor, P., Shyong, Y. J., Samskey, N., Ho, K. Y., Radic, Z., Fenical, W., Sharpless, K. B., Kovarik, Z., & Camacho-Hernandez, G. A. (2021). Ligand design for human acetylcholinesterase and nicotinic acetylcholine receptors, extending beyond the conventional and canonical. Journal of Neurochemistry. https://doi.org/10.1111/jnc.15335

Purdy, T. N., Kim, M. C., Cullum, R., Fenical, W., & Moore, B. S. (2021). Discovery and biosynthesis of tetrachlorizine reveals enzymatic benzylic dehydrogenation via an ortho-quinone methide. Journal of the American Chemical Society, 143(10), 3682–3686. https://doi.org/10.1021/jacs.0c12415

Nair, V., Kim, M. C., Golen, J. A., Rheingold, A. L., Castro, G. A., Jensen, P. R., & Fenical, W. (2020). Verrucosamide, a cytotoxic 1,4-thiazepane-containing thiodepsipeptide from a marine-derived actinomycete. Marine Drugs, 18(11). https://doi.org/10.3390/md18110549

Lee, J., Gamage, C. D. B., Kim, G. J., Hillman, P. F., Lee, C., Lee, E. Y., Choi, H., Kim, H., Nam, S. J., & Fenical, W. (2020). Androsamide, a cyclic tetrapeptide from a marine Nocardiopsis sp., suppresses motility of colorectal cancer cells. Journal of Natural Products, 83(10), 3166–3172. https://doi.org/10.1021/acs.jnatprod.0c00815

Kim, M. C., Winter, J. M., Cullum, R., Li, Z. F., & Fenical, W. (2020). Complementary genomic, bioinformatics, and chemical approaches facilitate the absolute structure assignment of lonostatin, a linear polyketide from a rare marine-derived actinomycete. Acs Chemical Biology, 15(9), 2507–2515. https://doi.org/10.1021/acschembio.0c00526

da Silva, R. M., Carrao, D. B., Habenschus, M. D., Jimenez, P. C., Lops, N. P., Fenical, W., Costa-Lotufo, L. V., & de Oliveira, A. R. M. (2020). Prediction of seriniquinone-drug interactions by in vitro inhibition of human cytochrome P450 enzymes. Toxicology in Vitro, 65. https://doi.org/10.1016/j.tiv.2020.104820

Kim, M. C., Cullum, R., Hebishy, A. M. S., Mohamed, H. A., Faraag, A. H. I., Salah, N. M., Abdelfattah, M. S., & Fenical, W. (2020). Mersaquinone, a new tetracene derivative from the marine-derived Streptomyces sp. EG1 exhibiting activity against Methicillin-Resistant Staphylococcus aureus (MRSA). Antibiotics-Basel, 9(5). https://doi.org/10.3390/antibiotics9050252

Bai, R., Cruz-Monserrate, Z., Fenical, W., Pettit, G. R., & Hamel, E. (2020). Interaction of diazonamide A with tubulin. Archives of Biochemistry and Biophysics, 680. https://doi.org/10.1016/j.abb.2019.108217

Duggan, B. M., Cullum, R., Fenical, W., Amador, L. A., Rodriguez, A. D., & La Clair, J. J. (2019). Searching for small molecules with an atomic sort. Angewandte Chemie-International Edition. https://doi.org/10.1002/anie.201911862

Kim, M. C., Cullum, R., Machado, H., Smith, A. J., Yang, I., Rodvold, J. J., & Fenical, W. (2019). Photopiperazines A-D, photosensitive interconverting diketopiperazines with significant and selective activity against U87 glioblastoma cells, from a rare, marine-derived actinomycete of the family Streptomycetaceae. Journal of Natural Products, 82(8), 2262–2267. https://doi.org/10.1021/acs.jnatprod.9b00429

Ryu, M. J., Hwang, S., Kim, S., Yang, I., Oh, D. C., Nam, S. J., & Fenical, W. (2019). Meroindenon and merochlorins E and F, antibacterial meroterpenoids from a marine-derived sediment bacterium of the genus Streptomyces. Organic Letters, 21(15), 5779–5783. https://doi.org/10.1021/acs.orglett.9b01440

Zhou, X. F., Liang, Z., Li, K. L., Fang, W., Tian, Y. X., Luo, X. W., Chen, Y. L., Zhan, Z. K., Zhang, T., Liao, S. R., Liu, S. W., Liu, Y. H., Fenical, W., & Tang, L. (2019). Exploring the natural piericidins as anti-renal cell carcinoma agents targeting peroxiredoxin 1. Journal of Medicinal Chemistry, 62(15), 7058–7069. https://doi.org/10.1021/acs.jmedchem.9b00598

Shang, Z., Winter, J. M., Kauffman, C. A., Yang, I., & Fenical, W. (2019). Salinipeptins: Integrated genomic and chemical approaches reveal unusual D-amino acid-containing ribosomally synthesized and post-translationally modified peptides (RiPPs) from a Great Salt Lake Streptomyces sp. Acs Chemical Biology, 14(3), 415–425. https://doi.org/10.1021/acschembio.8b01058

Le, T. C., Lee, E. J., Lee, J., Hong, A., Yim, C. Y., Yang, I., Choi, H., Chin, J., Cho, S. J., Ko, J., Hwang, H., Nam, S. J., & Fenical, W. (2019). Saccharoquinoline, a cytotoxic alkaloidal meroterpenoid from marine-derived bacterium Saccharomonospora sp. Marine Drugs, 17(2). https://doi.org/10.3390/md17020098

Hammons, J. C., Trzoss, L., Jimenez, P. C., Hirata, A. S., Costa-Lotufo, L. V., La Clair, J. J., & Fenical, W. (2019). Advance of seriniquinone analogues as melanoma agents. Acs Medicinal Chemistry Letters, 10(2), 186–190. https://doi.org/10.1021/acsmedchemlett.8b00391

Kim, M. C., Machado, H., Jang, K. H., Trzoss, L., Jensen, P. R., & Fenical, W. (2018). Integration of Genomic Data with NMR Analysis Enables Assignment of the Full Stereostructure of Neaumycin B, a Potent Inhibitor of Glioblastoma from a Marine-Derived Micromonospora. Journal of the American Chemical Society, 140(34), 10775–10784. https://doi.org/10.1021/jacs.8b04848

Leutou, A. S., Yang, I. H., Le, T. C., Hahn, D., Lim, K. M., Nam, S. J., & Fenical, W. (2018). Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis. Journal of Antibiotics, 71(6), 609–612. https://doi.org/10.1038/s41429-018-0033-3

Zheng, J., McKinnie, S. M. K., El Gama, A., Fengit, W., Dong, Y., Agarwal, V., Fenical, W., Kumar, A., Cao, Z. Y., Moore, B. S., & Pessah, I. N. (2018). Organohalogens naturally biosynthesized in marine environments and produced as disinfection byproducts alter sarco/endoplasmic reticulum ca2+ dynamics. Environmental Science & Technology, 52(9), 5469–5478. https://doi.org/10.1021/acs.est.8b00512

da Silva, R. M., Guaratini, T., Jimenez, P. C., Fenical, W., Costa-Lotufo, L. V., Vessecchi, R., & Lopes, N. P. (2018). Mass spectrometry analysis of protonated marine natural product seriniquinone. Journal of the Brazilian Chemical Society, 29(5), 1162–1166. https://doi.org/10.21577/0103-5053.20180037

Nakatsuji, T., Chen, T. H., Butcher, A. M., Trzoss, L. L., Nam, S. J., Shirakawa, K. T., Zhou, W., Oh, J., Otto, M., Fenical, W., & Gallo, R. L. (2018). A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Science Advances, 4(2). https://doi.org/10.1126/sciadv.aao4502

Amos, G. C. A., Awakawa, T., Tuttle, R. N., Letzel, A. C., Kim, M. C., Kudo, Y., Fenical, W., Moore, B. S., & Jensen, P. R. (2017). Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality. Proceedings of the National Academy of Sciences of the United States of America, 114(52), E11121–E11130. https://doi.org/10.1073/pnas.1714381115

Yim, C. Y., Le, T. C., Lee, T. G., Yang, I., Choi, H., Lee, J., Kang, K. Y., Lee, J. S., Lim, K. M., Yee, S. T., Kang, H., Nam, S. J., & Fenical, W. (2017). Saccharomonopyrones A-C, New alpha-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp CNQ-490. Marine Drugs, 15(8). https://doi.org/10.3390/md15080239

Le, T. C., Yim, C. Y., Park, S., Katila, N., Yang, I., Song, M. C., Yoon, Y. J., Choi, D. Y., Choi, H., Nam, S. J., & Fenical, W. (2017). Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp. Bioorganic & Medicinal Chemistry Letters, 27(14), 3123–3126. https://doi.org/10.1016/j.bmcl.2017.05.035

Yang, I., Yoon, J., Kim, D., Hahn, D., Nam, S. J., & Fenical, W. (2017). 4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp. Tetrahedron Letters, 58(24), 2322–2324. https://doi.org/10.1016/j.tetlet.2017.03.088

Lee, H. W., Choi, H., Nam, S. J., Fenical, W., & Kim, H. (2017). Potent Inhibition of Monoamine Oxidase B by a Piloquinone from Marine-Derived Streptomyces sp CNQ-027. Journal of Microbiology and Biotechnology, 27(4), 785–790. https://doi.org/10.4014/jmb.1612.12025

Asolkar, R. N., Singh, A., Jensen, P. R., Aalbersberg, W., Carte, B. K., Feussner, K. D., Subramani, R., DiPasquale, A., Rheingold, A. L., & Fenical, W. (2017). Marinocyanins, cytotoxic bromo-phenazinone meroterpenoids from a marine bacterium from the streptomycete Glade MAR4. Tetrahedron, 73(16), 2234–2241. https://doi.org/10.1016/j.tet.2017.03.003

Kumar, A., Borgen, M., Aluwihare, L. I., & Fenical, W. (2017). Ozone-activated halogenation of mono- and dimethylbipyrrole in seawater. Environmental Science & Technology, 51(1), 589–595. https://doi.org/10.1021/acs.est.6b03601

Hay, A. J., Yang, M. H., Xia, X. Y., Liu, Z., Hammons, J., Fenical, W., & Zhu, J. (2017). Calcium enhances bile salt-dependent virulence activation in Vibrio cholerae. Infection and Immunity, 85(1). https://doi.org/10.1128/iai.00707-16

Beuzer, P., Axelrod, J., Trzoss, L., Fenical, W., Dasari, R., Evidente, A., Kornienko, A., Cang, H., & La Clair, J. J. (2016). Single dish gradient screening of small molecule localization. Organic & Biomolecular Chemistry, 14(35), 8241–8245. https://doi.org/10.1039/c6ob01418f

Zhou, X. F., & Fenical, W. (2016). The unique chemistry and biology of the piericidins. Journal of Antibiotics, 69(8), 582–593. https://doi.org/10.1038/ja.2016.7

La Clair, J. J., Fenical, W., & Costa-Lotufo, L. V. (2016). Elucidating the mode of action of marine natural products through an immunoaffinity fluorescent (iaf) approach. Journal of the Brazilian Chemical Society, 27(8), 1346–1354. https://doi.org/10.5935/0103-5053.20160148

Hassan, H. M., Boonlarppradab, C., & Fenical, W. (2016). Actinoquinolines A and B, anti-inflammatory quinoline alkaloids from a marine-derived Streptomyces sp., strain CNP975. Journal of Antibiotics, 69(7), 511–514. https://doi.org/10.1038/ja.2016.56

Lee, J., Han, C., Lee, T. G., Chin, J., Choi, H., Lee, W., Paik, M. J., Won, D. H., Jeong, G., Ko, J., Yoong, Y. J., Nam, S. J., Fenical, W., & Kang, H. (2016). Marinopyrones A-D, alpha-pyrones from marine-derived actinomycetes of the family Nocardiopsaceae. Tetrahedron Letters, 57(18), 1997–2000. https://doi.org/10.1016/j.tetlet.2016.03.084

Le, T. C., Yang, I., Yoon, Y. J., Nam, S. J., & Fenical, W. (2016). Ansalactams B-D illustrate further biosynthetic plasticity within the ansamycin pathway. Organic Letters, 18(9), 2256–2259. https://doi.org/10.1021/acs.orglett.6b00892

Ruckert, C., Leipoldt, F., Zeyhle, P., Fenical, W., Jensen, P. R., Kalinowski, J., Heide, L., & Kaysser, L. (2015). Complete genome sequence of Streptomyces sp CNQ-509, a prolific producer of meroterpenoid chemistry. Journal of Biotechnology, 216, 140–141. https://doi.org/10.1016/j.jbiotec.2015.08.009

Jungmann, K., Jansen, R., Gerth, K., Huch, V., Krug, D., Fenical, W., & Muller, R. (2015). Two of a kind: The biosynthetic pathways of chlorotonil and anthracimycin. Acs Chemical Biology, 10(11), 2480–2490. https://doi.org/10.1021/acschembio.5b00523

Leutou, A. S., Yang, I., Kang, H., Seo, E. K., Nam, S. J., & Fenical, W. (2015). Nocarimidazoles A and B from a marine-derived actinomycete of the genus Nocardiopsis. Journal of Natural Products, 78(11), 2846–2849. https://doi.org/10.1021/acs.jnatprod.5b00746

Puyana, M., Pawlik, J., Blum, J., & Fehical, W. (2015). Metabolite variability Caribbean sponges of the genus Aplysina. Revista Brasileira De Farmacognosia-Brazilian Journal of Pharmacognosy, 25(6), 592–599. https://doi.org/10.1016/j.bjp.2015.08.002

Choi, E. J., Nam, S. J., Paul, L., Beatty, D., Kauffman, C. A., Jensen, P. R., & Fenical, W. (2015). Previously uncultured marine bacteria linked to novel alkaloid production. Chemistry & Biology, 22(9), 1270–1279. https://doi.org/10.1016/j.chembiol.2015.07.014

Alvarez-Mico, X., Rocha, D. D., Guimaraes, L. A., Ambrose, A., Chapman, E., Costa-Lotufo, L. V., La Clair, J. J., & Fenical, W. (2015). The hybrid pyrroloisoindolone-dehydropyrrolizine alkaloid (-)-chlorizidine a targets proteins within the glycolytic pathway. Chembiochem, 16(14), 2002–2006. https://doi.org/10.1002/cbic.201500229