Hirata, A. S., La Clair, J. J., Jimenez, P. C., Costa-Lotufo, L. V., & Fenical, W. (2022). Preclinical Development of Seriniquinones as Selective Dermcidin Modulators for the Treatment of Melanoma. Marine Drugs, 20(5).
Castro-Falcon, G., Creamer, K. E., Chase, A. B., Kim, M. C., Sweeney, D., Glukhov, E., Fenical, W., & Jensen, P. R. (2022). Structure and candidate biosynthetic gene cluster of a manumycin-type metabolite from Salinispora pacifica. Journal of Natural Products, 85(4), 980–986.
Shing, B., Balen, M., Fenical, W., & Debnath, A. (2022). Development of a machine learning-based cysticidal assay and identification of an amebicidal and cysticidal marine microbial metabolite against Acanthamoeba. Microbiology Spectrum, 10.
Lee, S. E., Kim, M. J., Hillman, P. F., Oh, D. C., Fenical, W., Nam, S. J., & Lim, K. M. (2022). Deoxyvasicinone with anti-melanogenic activity from marine-derived Streptomyces sp. CNQ-617. Marine Drugs, 20(2).
Kim, S., Le, T. C., Han, S. A., Hillman, P. F., Hong, A., Hwang, S., Du, Y. E., Kim, H., Oh, D. C., Cha, S. S., Lee, J., Nam, S. J., & Fenical, W. (2022). Saccharobisindole, neoasterric methyl ester, and 7-chloro-4(1H)-quinolone: Three new compounds isolated from the marine bacterium Saccharomonospora sp. Marine Drugs, 20(1), 12.
Le, T. C., Pulat, S., Lee, J., Kim, G. J., Kim, H., Lee, E. Y., Hillman, P. F., Choi, H., Yang, I., Oh, D. C., Nam, S. J., & Fenical, W. (2022). Marine depsipeptide nobilamide i inhibits cancer cell motility and tumorigenicity via suppressing epithelial-mesenchymal transition and MMP2/9 expression. Acs Omega, 11.
Kim, M. C., Li, Z. F., Cullum, R., Molinski, T. F., Eid, M. A. G., Hebishy, A. M. S., Faraag, A. H. I., Moneim, A. E. A., Abdelfattah, M. S., & Fenical, W. (2022). Chlororesistoflavins A and B, Chlorinated Benzopyrene Antibiotics Produced by the Marine-Derived Actinomycete Streptomyces sp. Strain EG32. Journal of Natural Products, 6.
Hirata, A. S., Rezende-Teixeira, P., Machado-Neto, J. A., Jimenez, P. C., Clair, J. J. L., Fenical, W., & Costa-Lotufo, L. V. (2021). Seriniquinones as therapeutic leads for treatment of BRAF and NRAS mutant melanomas. Molecules, 26(23), 15.
Kim, M. C., Winter, J. M., Asolkar, R. N., Boonlarppradab, C., Cullum, R., & Fenical, W. (2021). Marinoterpins A-C: Rare linear merosesterterpenoids from marine-derived actinomycete bacteria of the family Streptomycetaceae. Journal of Organic Chemistry, 86(16), 11140–11148.
Kim, S., Lee, C. W., Park, S. Y., Asolkar, R. N., Kim, H., Kim, G. J., Oh, S. J., Kim, Y., Lee, E. Y., Oh, D. C., Yang, I., Paik, M. J., Choi, H., Nam, S. J., & Fenical, W. (2021). Acremonamide, a cyclic pentadepsipeptide with wound-healing properties isolated from a marine-derived fungus of the genus Acremonium. Journal of Natural Products, 84(8), 2249–2255.
Taylor, P., Shyong, Y. J., Samskey, N., Ho, K. Y., Radic, Z., Fenical, W., Sharpless, K. B., Kovarik, Z., & Camacho-Hernandez, G. A. (2021). Ligand design for human acetylcholinesterase and nicotinic acetylcholine receptors, extending beyond the conventional and canonical. Journal of Neurochemistry.
Purdy, T. N., Kim, M. C., Cullum, R., Fenical, W., & Moore, B. S. (2021). Discovery and biosynthesis of tetrachlorizine reveals enzymatic benzylic dehydrogenation via an ortho-quinone methide. Journal of the American Chemical Society, 143(10), 3682–3686.
Nair, V., Kim, M. C., Golen, J. A., Rheingold, A. L., Castro, G. A., Jensen, P. R., & Fenical, W. (2020). Verrucosamide, a cytotoxic 1,4-thiazepane-containing thiodepsipeptide from a marine-derived actinomycete. Marine Drugs, 18(11).
Lee, J., Gamage, C. D. B., Kim, G. J., Hillman, P. F., Lee, C., Lee, E. Y., Choi, H., Kim, H., Nam, S. J., & Fenical, W. (2020). Androsamide, a cyclic tetrapeptide from a marine Nocardiopsis sp., suppresses motility of colorectal cancer cells. Journal of Natural Products, 83(10), 3166–3172.
Kim, M. C., Winter, J. M., Cullum, R., Li, Z. F., & Fenical, W. (2020). Complementary genomic, bioinformatics, and chemical approaches facilitate the absolute structure assignment of lonostatin, a linear polyketide from a rare marine-derived actinomycete. Acs Chemical Biology, 15(9), 2507–2515.
da Silva, R. M., Carrao, D. B., Habenschus, M. D., Jimenez, P. C., Lops, N. P., Fenical, W., Costa-Lotufo, L. V., & de Oliveira, A. R. M. (2020). Prediction of seriniquinone-drug interactions by in vitro inhibition of human cytochrome P450 enzymes. Toxicology in Vitro, 65.
Kim, M. C., Cullum, R., Hebishy, A. M. S., Mohamed, H. A., Faraag, A. H. I., Salah, N. M., Abdelfattah, M. S., & Fenical, W. (2020). Mersaquinone, a new tetracene derivative from the marine-derived Streptomyces sp. EG1 exhibiting activity against Methicillin-Resistant Staphylococcus aureus (MRSA). Antibiotics-Basel, 9(5).
Bai, R., Cruz-Monserrate, Z., Fenical, W., Pettit, G. R., & Hamel, E. (2020). Interaction of diazonamide A with tubulin. Archives of Biochemistry and Biophysics, 680.
Duggan, B. M., Cullum, R., Fenical, W., Amador, L. A., Rodriguez, A. D., & La Clair, J. J. (2019). Searching for small molecules with an atomic sort. Angewandte Chemie-International Edition.
Kim, M. C., Cullum, R., Machado, H., Smith, A. J., Yang, I., Rodvold, J. J., & Fenical, W. (2019). Photopiperazines A-D, photosensitive interconverting diketopiperazines with significant and selective activity against U87 glioblastoma cells, from a rare, marine-derived actinomycete of the family Streptomycetaceae. Journal of Natural Products, 82(8), 2262–2267.
Ryu, M. J., Hwang, S., Kim, S., Yang, I., Oh, D. C., Nam, S. J., & Fenical, W. (2019). Meroindenon and merochlorins E and F, antibacterial meroterpenoids from a marine-derived sediment bacterium of the genus Streptomyces. Organic Letters, 21(15), 5779–5783.
Zhou, X. F., Liang, Z., Li, K. L., Fang, W., Tian, Y. X., Luo, X. W., Chen, Y. L., Zhan, Z. K., Zhang, T., Liao, S. R., Liu, S. W., Liu, Y. H., Fenical, W., & Tang, L. (2019). Exploring the natural piericidins as anti-renal cell carcinoma agents targeting peroxiredoxin 1. Journal of Medicinal Chemistry, 62(15), 7058–7069.
Shang, Z., Winter, J. M., Kauffman, C. A., Yang, I., & Fenical, W. (2019). Salinipeptins: Integrated genomic and chemical approaches reveal unusual D-amino acid-containing ribosomally synthesized and post-translationally modified peptides (RiPPs) from a Great Salt Lake Streptomyces sp. Acs Chemical Biology, 14(3), 415–425.
Le, T. C., Lee, E. J., Lee, J., Hong, A., Yim, C. Y., Yang, I., Choi, H., Chin, J., Cho, S. J., Ko, J., Hwang, H., Nam, S. J., & Fenical, W. (2019). Saccharoquinoline, a cytotoxic alkaloidal meroterpenoid from marine-derived bacterium Saccharomonospora sp. Marine Drugs, 17(2).
Hammons, J. C., Trzoss, L., Jimenez, P. C., Hirata, A. S., Costa-Lotufo, L. V., La Clair, J. J., & Fenical, W. (2019). Advance of seriniquinone analogues as melanoma agents. Acs Medicinal Chemistry Letters, 10(2), 186–190.
Kim, M. C., Machado, H., Jang, K. H., Trzoss, L., Jensen, P. R., & Fenical, W. (2018). Integration of Genomic Data with NMR Analysis Enables Assignment of the Full Stereostructure of Neaumycin B, a Potent Inhibitor of Glioblastoma from a Marine-Derived Micromonospora. Journal of the American Chemical Society, 140(34), 10775–10784.
Leutou, A. S., Yang, I. H., Le, T. C., Hahn, D., Lim, K. M., Nam, S. J., & Fenical, W. (2018). Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis. Journal of Antibiotics, 71(6), 609–612.
Zheng, J., McKinnie, S. M. K., El Gama, A., Fengit, W., Dong, Y., Agarwal, V., Fenical, W., Kumar, A., Cao, Z. Y., Moore, B. S., & Pessah, I. N. (2018). Organohalogens naturally biosynthesized in marine environments and produced as disinfection byproducts alter sarco/endoplasmic reticulum ca2+ dynamics. Environmental Science & Technology, 52(9), 5469–5478.
da Silva, R. M., Guaratini, T., Jimenez, P. C., Fenical, W., Costa-Lotufo, L. V., Vessecchi, R., & Lopes, N. P. (2018). Mass spectrometry analysis of protonated marine natural product seriniquinone. Journal of the Brazilian Chemical Society, 29(5), 1162–1166.
Nakatsuji, T., Chen, T. H., Butcher, A. M., Trzoss, L. L., Nam, S. J., Shirakawa, K. T., Zhou, W., Oh, J., Otto, M., Fenical, W., & Gallo, R. L. (2018). A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Science Advances, 4(2).
Amos, G. C. A., Awakawa, T., Tuttle, R. N., Letzel, A. C., Kim, M. C., Kudo, Y., Fenical, W., Moore, B. S., & Jensen, P. R. (2017). Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality. Proceedings of the National Academy of Sciences of the United States of America, 114(52), E11121–E11130.
Yim, C. Y., Le, T. C., Lee, T. G., Yang, I., Choi, H., Lee, J., Kang, K. Y., Lee, J. S., Lim, K. M., Yee, S. T., Kang, H., Nam, S. J., & Fenical, W. (2017). Saccharomonopyrones A-C, New alpha-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp CNQ-490. Marine Drugs, 15(8).
Le, T. C., Yim, C. Y., Park, S., Katila, N., Yang, I., Song, M. C., Yoon, Y. J., Choi, D. Y., Choi, H., Nam, S. J., & Fenical, W. (2017). Lodopyridones B and C from a marine sediment-derived bacterium Saccharomonospora sp. Bioorganic & Medicinal Chemistry Letters, 27(14), 3123–3126.
Yang, I., Yoon, J., Kim, D., Hahn, D., Nam, S. J., & Fenical, W. (2017). 4Z- and 4E-12-deoxydihydrokromycins, two naturally occurring kromycin aglycones of pikromycin from Streptomyces sp. Tetrahedron Letters, 58(24), 2322–2324.
Lee, H. W., Choi, H., Nam, S. J., Fenical, W., & Kim, H. (2017). Potent Inhibition of Monoamine Oxidase B by a Piloquinone from Marine-Derived Streptomyces sp CNQ-027. Journal of Microbiology and Biotechnology, 27(4), 785–790.
Asolkar, R. N., Singh, A., Jensen, P. R., Aalbersberg, W., Carte, B. K., Feussner, K. D., Subramani, R., DiPasquale, A., Rheingold, A. L., & Fenical, W. (2017). Marinocyanins, cytotoxic bromo-phenazinone meroterpenoids from a marine bacterium from the streptomycete Glade MAR4. Tetrahedron, 73(16), 2234–2241.
Kumar, A., Borgen, M., Aluwihare, L. I., & Fenical, W. (2017). Ozone-activated halogenation of mono- and dimethylbipyrrole in seawater. Environmental Science & Technology, 51(1), 589–595.
Hay, A. J., Yang, M. H., Xia, X. Y., Liu, Z., Hammons, J., Fenical, W., & Zhu, J. (2017). Calcium enhances bile salt-dependent virulence activation in Vibrio cholerae. Infection and Immunity, 85(1).
Beuzer, P., Axelrod, J., Trzoss, L., Fenical, W., Dasari, R., Evidente, A., Kornienko, A., Cang, H., & La Clair, J. J. (2016). Single dish gradient screening of small molecule localization. Organic & Biomolecular Chemistry, 14(35), 8241–8245.
Zhou, X. F., & Fenical, W. (2016). The unique chemistry and biology of the piericidins. Journal of Antibiotics, 69(8), 582–593.
La Clair, J. J., Fenical, W., & Costa-Lotufo, L. V. (2016). Elucidating the mode of action of marine natural products through an immunoaffinity fluorescent (iaf) approach. Journal of the Brazilian Chemical Society, 27(8), 1346–1354.
Hassan, H. M., Boonlarppradab, C., & Fenical, W. (2016). Actinoquinolines A and B, anti-inflammatory quinoline alkaloids from a marine-derived Streptomyces sp., strain CNP975. Journal of Antibiotics, 69(7), 511–514.
Lee, J., Han, C., Lee, T. G., Chin, J., Choi, H., Lee, W., Paik, M. J., Won, D. H., Jeong, G., Ko, J., Yoong, Y. J., Nam, S. J., Fenical, W., & Kang, H. (2016). Marinopyrones A-D, alpha-pyrones from marine-derived actinomycetes of the family Nocardiopsaceae. Tetrahedron Letters, 57(18), 1997–2000.
Le, T. C., Yang, I., Yoon, Y. J., Nam, S. J., & Fenical, W. (2016). Ansalactams B-D illustrate further biosynthetic plasticity within the ansamycin pathway. Organic Letters, 18(9), 2256–2259.
Ruckert, C., Leipoldt, F., Zeyhle, P., Fenical, W., Jensen, P. R., Kalinowski, J., Heide, L., & Kaysser, L. (2015). Complete genome sequence of Streptomyces sp CNQ-509, a prolific producer of meroterpenoid chemistry. Journal of Biotechnology, 216, 140–141.
Jungmann, K., Jansen, R., Gerth, K., Huch, V., Krug, D., Fenical, W., & Muller, R. (2015). Two of a kind: The biosynthetic pathways of chlorotonil and anthracimycin. Acs Chemical Biology, 10(11), 2480–2490.
Leutou, A. S., Yang, I., Kang, H., Seo, E. K., Nam, S. J., & Fenical, W. (2015). Nocarimidazoles A and B from a marine-derived actinomycete of the genus Nocardiopsis. Journal of Natural Products, 78(11), 2846–2849.
Puyana, M., Pawlik, J., Blum, J., & Fehical, W. (2015). Metabolite variability Caribbean sponges of the genus Aplysina. Revista Brasileira De Farmacognosia-Brazilian Journal of Pharmacognosy, 25(6), 592–599.
Choi, E. J., Nam, S. J., Paul, L., Beatty, D., Kauffman, C. A., Jensen, P. R., & Fenical, W. (2015). Previously uncultured marine bacteria linked to novel alkaloid production. Chemistry & Biology, 22(9), 1270–1279.
Alvarez-Mico, X., Rocha, D. D., Guimaraes, L. A., Ambrose, A., Chapman, E., Costa-Lotufo, L. V., La Clair, J. J., & Fenical, W. (2015). The hybrid pyrroloisoindolone-dehydropyrrolizine alkaloid (-)-chlorizidine a targets proteins within the glycolytic pathway. Chembiochem, 16(14), 2002–2006.