WILLIAM FENICAL
Emeritus
CTR FOR MARINE BIOTEC & BIOMED
Distinguished Professor of Oceanography
Research Interests
- Chemistry of marine plants, microorganisms and invertebrate animals.
- Utilization of marine-derived compounds for the treatment of various human diseases, in particular cancer and infectious diseases.
Degrees
- B.S., California State Polytechnic University
- M.S., San Jose State University
- PhD, University of California, Riverside
Recent Publications
9129767 PJFFIS8I 1 apa 5 date desc Fenical, W. 265 https://wfenical.scrippsprofiles.ucsd.edu/wp-content/plugins/zotpress/
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Bring Horvath, E. R., Brazelton, W. J., Kim, M. C., Cullum, R., Mulvey, M. A., Fenical, W., & Winter, J. M. (2024). Bacterial diversity and chemical ecology of natural product–producing bacteria from Great Salt Lake sediment. ISME Communications, 4(1), ycae029. https://doi.org/10.1093/ismeco/ycae029
Miguel, R. D. A., Hirata, A. S., Salata, G. C., Apolinário, A. C., Barroso, V. M., Ishida, K., La Clair, J. J., Fenical, W., Martins, T. S., Costa-Lotufo, L. V., & Lopes, L. B. (2024). Topical delivery of seriniquinone for treatment of skin cancer and fungal infections is enabled by a liquid crystalline lamellar phase. European Journal of Pharmaceutical Sciences, 192, 106635. https://doi.org/10.1016/j.ejps.2023.106635
Yuan, A., Fong, H., Nguyen, J. V., Nguyen, S., Norman, P., Cullum, R., Fenical, W., & Debnath, A. (2023). High-Throughput Screen of Microbial Metabolites Identifies F 1 F O ATP Synthase Inhibitors as New Leads for Naegleria fowleri Infection. ACS Infectious Diseases, 9(12), 2622–2631. https://doi.org/10.1021/acsinfecdis.3c00437
Shin, D., Byun, W. S., Kang, S., Kang, I., Bae, E. S., An, J. S., Im, J. H., Park, J., Kim, E., Ko, K., Hwang, S., Lee, H., Kwon, Y., Ko, Y.-J., Hong, S., Nam, S.-J., Kim, S. B., Fenical, W., Yoon, Y. J., … Oh, D.-C. (2023). Targeted and Logical Discovery of Piperazic Acid-Bearing Natural Products Based on Genomic and Spectroscopic Signatures. Journal of the American Chemical Society, 145(36), 19676–19690. https://doi.org/10.1021/jacs.3c04699
Pulat, S., Kim, D.-A., Hillman, P. F., Oh, D.-C., Kim, H., Nam, S.-J., & Fenical, W. (2023). Actinoquinazolinone, a New Quinazolinone Derivative from a Marine Bacterium Streptomyces sp. CNQ-617, Suppresses the Motility of Gastric Cancer Cells. Marine Drugs, 21(9), 489. https://doi.org/10.3390/md21090489